Gavin is the father of 19-year-old daughter, Daisy Lowe, from a previous relationship.
Stefani's second pregnancy was unintentionally announced by her father-in-law Douglas Rossdale in January.
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The couple and several family members were escorted by police from their Hollywood Hills home to the maternity ward of Cedars Sinai medical center where Gwen delivered the 8 lbs, 5 ounce baby.
LOS ANGELES (AP) — It's Love, Angel, Music, and Baby No. 2 for Gwen Stefani, who on Thursday gave birth to a boy. Zuma Nesta Rock weighed 8 pounds and 5 ounces when he was born Thursday afternoon, according to publicist Dave Tomberlin.
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"Mother, baby and family are all happy and healthy," he said in a statement.
The pop star and fashionista already has one son, Kingston, with her husband, rocker Gavin Rossdale. Rossdale also has a teenage daughter with fashion designer Pearl Lowe.
Stefani has racked up numerous hits and best-selling albums over the years, not only as a solo artist, but as the front woman for the band No Doubt. But the 38-year-old has also become a successful designer with her L.A.M.B. and other clothing lines.
Her last album, "The Sweet Escape," was released in 2006, a follow-up to 2004's multiplatinum "Love. Angel. Music. Baby."